To become a Vampire Lord again, they need to ask Serana or Harkon (if sided with the vampires). In Dawnguard, if the Dragonborn is cured of Lycanthropy or becomes a Vampire Lord, they can talk to Aela and she can make them a werewolf again, canceling out vampirism. This is temporary and the Dragonborn does not contract lycanthropy.

The Dragonborn may also become a werewolf when wearing the Ring of Hircine during the quest ' Ill Met by Moonlight' for the Daedric Prince Hircine. After the Dragonborn 'feeds' or just waits, the screen blacks out, then the Dragonborn turns back to their original form, unclothed, and begins being questioned by Aela the Huntress. Lycanthropy is contracted as part of the blood ritual that occurs during the Companions quest, ' The Silver Hand.' The first transformation through this disease vector is particularly violent, allowing the Dragonborn to prowl outside The Underforge of Whiterun in bestial form there are two exits, one to the city, and a one-way exit to the eastern environs. This resembles a standard power in that it can be marked as a favorite and assigned a quick-change number as any other power, spell, shout, weapon, or armor. The process by which the Dragonborn becomes a werewolf is activated through the Magic menu, Powers tab: Beast Form. The only way to get this disease is by progressing through the Companions questline. If the Dragonborn contracts Lycanthropy, they will have the ability to turn into a werewolf. Werewolves in Skyrim have less fur than the Bloodmoon werewolves, their arms are longer and possess more strength.

Their eyes in wolf form are yellow, while in human form the eyes of an NPC werewolf are silver. Unlike the more wolf-faced look of the Bloodmoon werewolves, the werewolves of Skyrim have monstrous faces and muscular builds. The appearance of the werewolf in Skyrim is that of a large wolf-like humanoid creature with razor sharp claws and a set of large teeth.

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